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Taking ICLUSIG® (ponatinib)

The following is information to help you learn about taking ICLUSIG. Talk to your healthcare provider about the importance of taking ICLUSIG exactly as prescribed.

How should I take ICLUSIG?

Talk with your healthcare provider if you have any questions about how to take ICLUSIG.
Before taking ICLUSIG, tell your healthcare provider about all the medicines you take, including prescription medicines and over-the-counter medicines, vitamins, and herbal supplements. ICLUSIG may affect other medicines and may cause side effects.

How does dosing work?

ICLUSIG is prescribed in multiple dose strengths to fit your individual treatment needs. The starting dose is usually 45 mg or 30 mg. Your healthcare provider will start you on the dose that is appropriate for you.
Your healthcare provider may decide to lower your dose if you have a good response to ICLUSIG. If you experience side effects, your HCP may also reduce your dose, stop for a short time, or permanently stop treatment. Tell your medical team if you have side effects, and ask your healthcare provider about your dose and how it may change over time.

45 mg

The recommended starting dose of ICLUSIG is 45 mg once daily. This dose comes in tablets stamped AP4.

30 mg

If you have liver problems, your healthcare provider may want you to start at 30 mg of ICLUSIG per day.
You may be taking some medications that may require your healthcare provider to start you at 30 mg of ICLUSIG per day.

15 mg

If you experience some side effects, your healthcare provider may prescribe you a lower dose of ICLUSIG: either 30 mg or 15 mg per day.
Patients prescribed a lower dose will receive their ICLUSIG in 15 mg tablets stamped A5.

The optimal dose of ICLUSIG has not yet been identified.

What should I tell my healthcare provider
before taking ICLUSIG?

It is important to discuss all potential side effects with your healthcare provider. A more complete discussion of these side effects can be found in the Patient Medication Guide in the full Prescribing Information and in the ICLUSIG Important Safety Information.

Before you take ICLUSIG, tell your healthcare provider about all of your medical conditions, including if you:

  • have a history of blood clots in your blood vessels (arteries or veins)
  • have heart problems, including heart failure, irregular heartbeats, and QT prolongation
  • have diabetes
  • have a history of high cholesterol
  • have liver problems
  • have had inflammation of your pancreas (pancreatitis)
  • have high blood pressure
  • have bleeding problems
  • plan to have any surgical procedures or have had a recent surgery
  • are lactose (milk sugar) intolerant. ICLUSIG tablets contain lactose.
  • drink grapefruit juice
  • are pregnant or plan to become pregnant. ICLUSIG can harm your unborn baby.
    • Your healthcare provider will do a pregnancy test before you start taking ICLUSIG.
    • You should not become pregnant during treatment with ICLUSIG.
    • For females who can become pregnant:
      • — Use an effective form of birth control during treatment and for 3 weeks after your last dose of ICLUSIG.
      • — Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with ICLUSIG.
      • — ICLUSIG may affect your ability to have children. Tell your healthcare provider if this is a concern for you.
  • are breastfeeding or plan to breastfeed. It is not known if ICLUSIG passes into your breast milk. Do not breastfeed during treatment and for 6 days after your last dose of ICLUSIG.

Tell your healthcare provider about all the medicines you take, including prescription medicines and over-the-counter medicines, vitamins, and herbal supplements. ICLUSIG and other medicines may affect each other causing side effects.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

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The information provided on this site is intended for informational purposes and cannot replace individualized guidance from a healthcare provider. Be sure to talk with your healthcare provider about making any change to your healthcare regimen. The information on this site is intended for residents of the United States only. Product labeling may be different in other countries.